Notice of Special Interest (NOSI): Sleep and Substance Use Disorders
This notice is to inform potential applicants to the National Institute on Drug Abuse (NIDA) about a special interest in research project applications focusing on the relationship between processes that regulate sleep/circadian rhythm and the risk, trajectory and treatment of substance use disorders.
Selected examples of possible research include:
Elucidate neurobiological mechanisms through which sleep deficiency or circadian disruption modifies reward, affect, executive function, pain, and other processes that can contribute to susceptibility to SUD.
Identify mechanisms by which sleep deficiency or circadian disruption modifies the trajectory of SUD including initiation, maintenance, withdrawal, abstinence, relapse and the course of recovery.
Mechanisms by which of drugs of abuse induce sleep or circadian dysregulation.
Behavioral/pharmacological mechanisms to improve sleep dysregulation in SUD
Use of sleep architecture as biomarkers of SUD severity and recovery.
Circadian-dependent pharmacological mechanisms contributing to drug tolerance, withdrawal, and MAT response (e.g. do the effects of drugs of abuse vary depending of time of day of administration?).