This notice is to inform potential applicants to the National Institute on Drug Abuse (NIDA) about a special interest in research project applications focusing on the relationship between processes that regulate sleep/circadian rhythm and the risk, trajectory and treatment of substance use disorders.
Selected examples of possible research include:
- Elucidate neurobiological mechanisms through which sleep deficiency or circadian disruption modifies reward, affect, executive function, pain, and other processes that can contribute to susceptibility to SUD.
- Identify mechanisms by which sleep deficiency or circadian disruption modifies the trajectory of SUD including initiation, maintenance, withdrawal, abstinence, relapse and the course of recovery.
- Mechanisms by which of drugs of abuse induce sleep or circadian dysregulation.
- Behavioral/pharmacological mechanisms to improve sleep dysregulation in SUD
- Use of sleep architecture as biomarkers of SUD severity and recovery.
Circadian-dependent pharmacological mechanisms contributing to drug tolerance, withdrawal, and MAT response (e.g. do the effects of drugs of abuse vary depending of time of day of administration?).